EMP3 (epithelial membrane protein 3)

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URI:http://hdl.handle.net/2042/62497  |   DOI : 10.4267/2042/62497
Title: EMP3 (epithelial membrane protein 3)
Author:Mellai, Marta; Schiffer, Davide
Abstract:Epithelial membrane protein 3 (EMP3) has recently been proposed as a candidate tumor suppressor gene (TSG) for some kinds of solid tumors. EMP3 down-regulation has been explained by its epigenetic silencing through aberrant hypermethylation of the promoter region. EMP3 repression in cancer seems to be an organ-specific phenomenon, common in neuroblastoma and gliomas, relatively common in breast cancer, and rare in esophageal squamous cell carcinoma (ESCC). Among cancer-derived cell lines, it prevails in neuroblastoma, breast cancer and ESCC whereas it is rare in glioma, non-small cell lung carcnoma (NSCLC), gastric and colon cancer-derived cell lines. EMP3 expression level is associated with clinical prognosis in neuoblastoma, ESCC, NSCLC and upper urinary tract urothelial carcinoma. In contrast, EMP3 expression may be a novel marker of tumor aggressiveness in breast cancer whereas in gliomas, EMP3 represssion by aberrant hypermethylation has a prognostic signifcance. In both tumor types, however, alternative mechanisms to the EMP3 epigenetic silencing may exist to explain EMP3 down-regulation. Moreover, EMP3 may be involved in the prostate cancer suscpetibility.
Subject:Epithelial membrane protein 3 (EMP3); tumor suppressor gene; solid tumors; promoter hypermethylation; prognosis; Genes Section
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2015

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