FAS (Fas cell surface death receptor)

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URI: http://hdl.handle.net/2042/62486  |   DOI : https://doi.org/10.4267/2042/62486
Title: FAS (Fas cell surface death receptor)
Author: Sanséau, Doriane; Legembre, Patrick
Abstract: CD95 (also known as Fas) is a death receptor that belongs to the TNF-receptor superfamily. Expressed at the cell surface as a homotrimer, this receptor implements both apoptotic and non-apoptotic signalling pathways. While the apoptotic signalling pathway is involved in tumor surveillance, peripheral tolerance and immune homeostasis (Strasser et al., 2009), its non-apoptotic cues seem to promote oncogenesis (Chen et al., 2010; Hoogwater et al., 2010; Kleber et al., 2010; Malleter et al., 2013; Steller et al., 2011).
Subject: CD95; Fas; apoptosis; inflammation; auto-immunity; metastasis; Genes Section
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2015

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