ITGA1 (integrin, alpha 1)

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Title: ITGA1 (integrin, alpha 1)
Author: Boudjadi, Salah; Beaulieu, Jean-François
Abstract: The α1 integrin subunit (SU) belongs to a large family of α and β subunits that are noncovalently linked to constitute αβ transmembrane units. To date, 18 α and 8 β subunits are known to form 24 αβ units (Takada et al., 2007; Barczyk et al., 2010) which are involved in cell-cell and cell-matrix attachment and can drive inside-out and outside-in cell signaling (Shattil et al., 2010). Integrins are known to participate in different cell processes including cell shape, differentiation, migration, survival and proliferation (Giancotti, 1997; Vachon, 2011; Beauséjour et al., 2012). The &alpha ;1 SU was discovered in 1986 as the Very Late Antigen 1 (VLA1) and is highly expressed in activated lymphocytes in the joints of patients with rheumatoid arthritis (Hemler et al., 1986). In fibroblasts, α1 is known to activate the RAS/ERK proliferative pathway and has a pro-invasive function in certain cancers. In megakaryocyte differentiation α1 is silenced by DNA methylation but not histone modification (Cheli et al., 2007). Different transcription factors involved in cancer progression can bind to the ITGA1 promoter. Integrin α1 transcriptional regulation remains to be further defined.
Subject: ITGA1; Genes Section; Humans; Animals; Signal Transduction; *Signal Transduction; Mice; Cell Adhesion; Phenotype; Integrin alpha1; Cytoplasm/*metabolism; Cell Proliferation; Cell Movement/physiology; Tumor Cells, Cultured; Transcription, Genetic; *Transcription, Genetic; T-Lymphocytes/*immunology; Thrombopoietin/pharmacology; Talin/*metabolism; Synovial Fluid/*immunology; Survival Analysis; Signal Transduction/*physiology
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2015

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