BIRC6 (Baculoviral IAP repeat-containing 6)

Show simple item record Luk, Sze Ue Iris - Wang, Yuzhuo - 2017-06-28T06:57:18Z 2017-06-28T06:57:18Z 2015 -
dc.identifier.citation Sze Ue Iris, Luk ; Yuzhuo, Wang. BIRC6 (Baculoviral IAP repeat-containing 6). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2015, 9, p. 559-564 -
dc.identifier.issn 1768-3262
dc.description.abstract The BIRC6 gene (BRUCE/APOLLON) encodes the cytoplasmic protein BIRC6 in mammals, consisting of a single N-terminal baculoviral IAP repeat (BIR) domain and a C-terminal ubiquitin-conjugating (UBC) domain. Of the huge protein size at 528 kDa, BIRC6 demonstrated pleiotropic functions including inhibition of apoptosis, cytoprotection, regulation of cytokinesis, mitosis, autophagy and neutrophil differentiation. With the BIR domain, BIRC6 is defined as a member of the Inhibitor of Apoptosis (IAP) family. Through its BIR domain, BIRC6 binds to active caspases, including caspases-3, 6, 7 and 9 and accounts for its ability to inhibit the caspase cascade and ultimately apoptosis. The UBC domain has chimeric E2/E3 ubiquitin ligase activity where it facilitates proteosomal degradation of various proteins, including pro-apoptotic proteins p53, caspases, Smac and mitotic regulator cyclin A. More importantly, the UBC domain plays an indispensable role in embryonic development in mammals and spermatogenesis in Drosophila. Increasing evidence supports the cancer promoting role of BIRC6. Elevated BIRC6 expression has been found in a variety of cancers and was shown to contribute to treatment resistance. en
dc.language.iso en -
dc.publisher Jean-Loup Huret (Editor-in-Chief) -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology
dc.rights Open access resource - terms and conditions : -
dc.subject BIRC6 en
dc.subject Apollon en
dc.subject BRUCE en
dc.subject Inhibitor of Apoptosis en
dc.subject BIR en
dc.subject UBC en
dc.subject E2/E3 ligase en
dc.subject.classification Genes Section en
dc.subject.mesh Humans en
dc.subject.mesh Female en
dc.subject.mesh Male en
dc.subject.mesh Animals en
dc.subject.mesh Mice en
dc.subject.mesh Inhibitor of Apoptosis Proteins/genetics/*metabolism en
dc.subject.mesh Cell Line, Tumor en
dc.subject.mesh Xenograft Model Antitumor Assays en
dc.subject.mesh RNA Interference en
dc.subject.mesh Prognosis en
dc.subject.mesh Middle Aged en
dc.subject.mesh HeLa Cells en
dc.subject.mesh Gene Expression Profiling en
dc.subject.mesh Cell Proliferation/drug effects en
dc.subject.mesh Apoptosis en
dc.subject.mesh Aged en
dc.title BIRC6 (Baculoviral IAP repeat-containing 6) en
dc.type Article -
dc.contributor.affiliation The Vancouver Prostate Centre, Vancouver General Hospital, Department of Urologic Sciences, the University of British Columbia, Vancouver, BC, Canada (SUIL, YW); Department of Experimental Therapeutics, BC Cancer Agency, Vancouver, BC, Canada (SUIL, YW) -

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