EYA2 (EYA transcriptional coactivator and phosphatase 2)

Show full item record

Files in this item

PDF 09-2014-EYA2ID46126ch20q13.pdf 516.3Kb

Pour citer ce document :
URI:http://hdl.handle.net/2042/62320  |   DOI : 10.4267/2042/62320
Title: EYA2 (EYA transcriptional coactivator and phosphatase 2)
Author:Zhang, Lingdi; Blevins, Melanie A.; Ford, Heide L.; Zhao, Rui
Abstract:EYA2 encodes a co-activator for the SIX family of homeobox transcription factors. The SIX/EYA transcriptional complex plays important roles in organogenesis, promoting the proliferation and survival of progenitor cells. Abnormal re-expression of EYA2 in adult tissue promotes tumorigenesis and metastasis in multiple tumor types. In addition to its role as a co-activator, the EYA Domain (ED) of EYA2 contains a unique HAD family Tyr phosphatase activity, which plays a role in ERβ specific anti-tumor activity in breast cancer. The EYA2 Tyr phosphatase can also dephosphorylate H2AX, potentially playing a role in DNA damage repair. The N-terminal region of EYA2 also contains a Ser/Thr phosphatase activity, which may regulate the innate immune response.
Subject:transcriptional co-activator; phosphatase; organogenesis; oncogenesis; EYA2; Genes Section; Humans; Animals; Mice; Female; Signal Transduction; Male; *Genomics; Genome, Human; *Genetic Variation; Cell Line, Tumor; Cell Line; Substrate Specificity; Structure-Activity Relationship; RNA Interference; Reverse Transcriptase Polymerase Chain Reaction
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2015

This item appears in the following Collection(s)

Show full item record





Advanced Search