EYA2 (EYA transcriptional coactivator and phosphatase 2)

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URI: http://hdl.handle.net/2042/62320  |   DOI : https://doi.org/10.4267/2042/62320
Title: EYA2 (EYA transcriptional coactivator and phosphatase 2)
Author: Zhang, Lingdi; Blevins, Melanie A.; Ford, Heide L.; Zhao, Rui
Abstract: EYA2 encodes a co-activator for the SIX family of homeobox transcription factors. The SIX/EYA transcriptional complex plays important roles in organogenesis, promoting the proliferation and survival of progenitor cells. Abnormal re-expression of EYA2 in adult tissue promotes tumorigenesis and metastasis in multiple tumor types. In addition to its role as a co-activator, the EYA Domain (ED) of EYA2 contains a unique HAD family Tyr phosphatase activity, which plays a role in ERβ specific anti-tumor activity in breast cancer. The EYA2 Tyr phosphatase can also dephosphorylate H2AX, potentially playing a role in DNA damage repair. The N-terminal region of EYA2 also contains a Ser/Thr phosphatase activity, which may regulate the innate immune response.
Subject: transcriptional co-activator; phosphatase; organogenesis; oncogenesis; EYA2; Genes Section; Humans; Animals; Mice; Female; Signal Transduction; Male; *Genomics; Genome, Human; *Genetic Variation; Cell Line, Tumor; Cell Line; Substrate Specificity; Structure-Activity Relationship; RNA Interference; Reverse Transcriptase Polymerase Chain Reaction
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2015

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