FABP5 (fatty acid binding protein 5 (psoriasis-associated))

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URI:http://hdl.handle.net/2042/62185  |   DOI : 10.4267/2042/62185
Title: FABP5 (fatty acid binding protein 5 (psoriasis-associated))
Author:Balcom, Erin; Liu, Rong-Zong; Poon, Stanley; Godbout, Roseline
Abstract:The FABP5 gene encodes a member of the fatty acid binding protein family which is also known as epidermal or cutaneous FABP. Overexpression of FABP5 is associated with a number of cancers including breast and prostate cancers, as well as psychiatric disorders and diabetes. FABP5 can bind retinoic acid as well as polyunsaturated and saturated fatty acids. Transport of FABP5 ligands such as arachidonic acid and retinoic acid to the nucleus is believed to activate the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARβ/δ).
Subject:fatty acid binding protein 5; fatty acids; retinoic acid; peroxisome proliferator-activated receptor; breast cancer; pro; Genes Section; Humans; 3-Phosphoinositide-Dependent Protein Kinases; Mice; Mice, Inbred C57BL; Male; Fatty Acid-Binding Proteins/genetics/*metabolism; Aged; Reverse Transcriptase Polymerase Chain Reaction; Protein Binding; Models, Molecular; Middle Aged; Mice, Knockout; Immunohistochemistry; Blotting, Western; Real-Time Polymerase Chain Reaction; Protein Structure, Tertiary; Prognosis; Neoplasm Proteins/genetics/*metabolism; Cells, Cultured
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2015

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