SOCS6 (Suppressor Of Cytokine Signaling 6)

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Title: SOCS6 (Suppressor Of Cytokine Signaling 6)
Author: Kazi, JU; Flores-Morales, A; Rönnstrand, L
Description: The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.
Subject: Chromosome 18; CIS-4 (alias); CIS4 (alias); HSPC060 (alias); SOCS-4 (alias); SOCS-6 (alias); SOCS4 (alias); SSI4 (alias); STAI4 (alias); STATI4 (alias); OTHER; Genes Section
Publisher: Jean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher)
Date: 2015

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