RRM2 (ribonucleotide reductase M2)

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URI: http://hdl.handle.net/2042/55375  |   DOI : https://doi.org/10.4267/2042/55375
Title: RRM2 (ribonucleotide reductase M2)
Author: Afrasiabi, A; Fiuji, F; Mirhafez, R; Avan, A
Description: Ribonucleotide reductase subunit M2 (RRM2) is located in chromosome-2 p25-p24, converts ribonucleotides to deoxynucleotides which is required for DNA polymerization and repair. It has been shown that RMM2 plays a key role in DNA synthesis, cell growth, and drug resistance of cancer cells. There is accumulating evidence that alteration in the expression level of RRM2 can have a substantial impact on the biological characteristics of cancer cells, including tumor initiation and progression, suggesting its role as a prognostic factor and a possible therapeutic target for cancer therapy. Therefore, this review highlights several recent and clinically relevant aspects of the expression and function of RRM2 in human cancer.
Subject: Chromosome 2; R2 (alias); RR2 (alias); RR2M (alias); OTHER; Genes Section
Publisher: Jean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher)
Date: 2015

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