ETV6 (ets variant 6)

Show simple item record De, Braekeleer E en_US Douet-Guilbert, N en_US De, Braekeleer M en_US 2014-11-24T10:53:17Z 2014-11-24T10:53:17Z 2014 en_US
dc.identifier.citation Atlas of Genetics and Cytogenetics in Oncology and Haematology; 2014, Vol. 18, N° 12 ; p. 886-899 en_US
dc.identifier.issn 1768-3262
dc.description The ETV6 gene located at band 12p13 encodes a protein containing two major domains, the HLH (helix-loop-helix) domain, encoded by exons 3 and 4, and the ETS domain, encoded by exons 6 through 8, with in between the internal domain encoded by exon 5. ETV6 is a strong transcriptional repressor, acting through its HLH and internal domains. Five potential mechanisms of ETV6-mediated carcinogenesis have been identified: constitutive activation of the kinase activity of the partner protein, modification of the original functions of a transcription factor, loss of function of the fusion gene, affecting ETV6 and the partner gene, activation of a proto-oncogene in the vicinity of a chromosomal translocation and dominant negative effect of the fusion protein over transcriptional repression mediated by wild-type ETV6. Thirty-three ETV6 partner genes have been identified. en_US
dc.language.iso en en_US
dc.publisher Jean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher) en_US
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; en_US
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology
dc.rights Open access resource - terms and conditions : en_US
dc.subject Chromosome 12 en_US
dc.subject TEL (alias) en_US
dc.subject TEL1 (alias) en_US
dc.subject Transcription factor en_US
dc.subject.classification Genes Section en_US
dc.title ETV6 (ets variant 6) en_US
dc.type Article en_US
dc.contributor.affiliation Cytogenetics Laboratory, Faculty of Medicine, University of Brest, France en_US

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