BAG3 (Bcl-2 associated athanogene 3)

Show simple item record d'Avenia, M en_US Guerriero, L en_US Rosati, A en_US Turco, MC en_US 2014-09-23T08:25:12Z 2014-09-23T08:25:12Z 2014 en_US
dc.identifier.citation Atlas of Genetics and Cytogenetics in Oncology and Haematology; 2014, Vol. 18, N° 10 ; p. 704-708 en_US
dc.identifier.issn 1768-3262 en_US
dc.description Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain. BAG3 is induced by stressful stimuli, mainly through the activity of heat shock factor 1 on bag3 gene promoter.In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70.These multifaceted interactions underlie BAG3 ability to modulate major biological processes, that is, apoptosis, development, cytoskeleton organization and autophagy, thereby mediating cell adaptive responses to stressful stimuli. In normal cells, BAG3 is constitutively present in a very few cell types, including cardiomyocytes and skeletal muscle cells, in which the protein appears to contribute to cell resistance to mechanical stress. BAG3 is expressed also in several tumor types where it sustains cell survival, resistance to therapy, and/or motility and metastatization (Rosati et al., 2011). en_US
dc.language.iso en en_US
dc.publisher Jean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher) en_US
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; en_US
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology
dc.rights Open access resource - terms and conditions : en_US
dc.subject Chromosome 10 en_US
dc.subject BAG-3 (alias) en_US
dc.subject BIS (alias) en_US
dc.subject CAIR-1 (alias) en_US
dc.subject MFM6 (alias) en_US
dc.subject Apoptosis en_US
dc.subject Cytoskeleton en_US
dc.subject Angiogenesis en_US
dc.subject Proteasome en_US
dc.subject Signal Secreted factor en_US
dc.subject PLCG en_US
dc.subject RAS-RAF-MAPK en_US
dc.subject NF-kB en_US
dc.subject.classification Genes Section en_US
dc.title BAG3 (Bcl-2 associated athanogene 3) en_US
dc.type Article en_US
dc.contributor.affiliation Department of Pharmaceutical and Biomedical Sciences (FARMABIOMED), University of Salerno, Fisciano (SA), Italy en_US

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