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Showing 10 out of a total of 150 results for community: Atlas of Genetics and Cytogenetics in Oncology and Haematology. (0.007 seconds)
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(Jean-Loup Huret (Editor-in-Chief), 2015)Review on AKAP1, with data on DNA, on the protein encoded, and where the gene is implicated....
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(Jean-Loup Huret (Editor-in-Chief), 2015)ADAM23 belongs to the ADAM (A Disintegrin And Metalloproteinase domain) family of proteins. Members of this family present a common structural organization including metalloprotease, disintegrin, cystein-rich, epidermal growth factor-like, transmembrane and cytoplasmatic domains and are structurally related to snake venom disintegrins. ADAM23 has close similarity to ADAM11 and ADAM22; is highly expressed in the CNS, and is crucial for normal brain development. Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia. ADAM23 does not present metalloprotease activity and probably plays its biological role through the disintegrin domain. ADAM23 is involved in cell-cell adhesion and communication and cell-matrix modulation. The ADAM23 gene is frequently silenced by DNA promoter methylation in different types of solid cancers and epigenetic inactivation is associated with cancer progression, increased tumor cell mobility and reduced tumor cell proliferation....
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(Jean-Loup Huret (Editor-in-Chief), 2015)FBXO11 is a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, named the F-box domain. It is the substrate binding subunit of the SKP1-CUL1-F-box (SCF) ubiquitin ligase complex. FBXO11 is conserved from nematodes to mammals, and both human FBXO11 and its worm ortholog (DRE-1) form functional SCF ubiquitin ligase complexes. By binding to and mediating the degradation of its substrate proteins, FBXO11 plays important roles in regulating cell cycle regulation, tumorigenesis, and tumor cell metastasis. The gene encoding FBXO11 was found to be deleted or mutated in various types of human tumors....
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(Jean-Loup Huret (Editor-in-Chief), 2015)ROS1 is proto-oncogene encoding a type I integral membrane protein with receptor tyrosine kinase (RTK) activity. ROS1 is a member of the insulin receptor family and is involved in downstream signalling processes involved in cell growth and differentiation....
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(ARMGHM - Atlas Génétique des Cancers, 2016)Review on ZAP70, with data on DNA, on the protein encoded, and where the gene is implicated....
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(Jean-Loup Huret (Editor-in-Chief), 2016)Review on STAT2, with data on DNA, on the protein encoded, and where the gene is implicated....
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(Jean-Loup Huret (Editor-in-Chief), 2016)The MECOM locus in chromosome band 3q26.2 gives rise to two major mRNA and protein species, EVI1 and MDS1/EVI1, of which the former has been characterized far more extensively. EVI1 has been implicated in the maintenance and expansion of normal hematopoietic stem cells. In addition, it plays a role as an oncogene in myeloid leukemia and in certain solid tumors, its overexpression being associated with a dismal prognosis in several of these malignancies. EVI1 exerts its biological effects mainly by regulating gene transcription, and does so by acting as a sequence specific transcription factor, by modulating the activity of other sequence specific transcription factors, and by regulating promoter CpG island methylation....
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(ARMGHM - Atlas Génétique des Cancers, 2016)Review on Cytochrome B5 Type A, with data on DNA/RNA, on the protein encoded and the diseases in which the gene has been implicated....
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(Jean-Loup Huret (Editor-in-Chief), 2016)BRD3 is a ubiquitously expressed member of the bromodomain and extraterminal motif (BET) family of proteins that use their tandem N-terminal bromodomains to associate with acetylated histones and transcription factors. Translocations involving BRD3 and NUT generate oncogenic fusion proteins that drive NUT midline carcinoma (NMC), an aggressive squamous cell malignancy. In addition, small molecule inhibitors that target the bromodomain-acetyl lysine interaction of all BET proteins are in clinical development for both hematologic malignancies and diverse solid tumors....
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(Jean-Loup Huret (Editor-in-Chief), 2015)The candidate tumor suppressor gene ZMYND10/BLU, is located on the minimal deleted fragment of 110 kb in chromosomal region 3p21.3. It was initially identified by PCR in search of the b-catenin homolog in lung cancer. BLU codes for a protein with 440 amino acid residues, which contains a zinc finger myelogenous nervy domain (zMYND) motif on its carboxyl terminus. The characteristic domain defines a ZMYNND protein family, some of its member have been found in the frequently affected region translocated during acute leukemias, and were described to be transcriptional repressors. BLU/ZMYND10 is inactivated in a variety of human tumors due to genetic or epigenetic mechanisms, but the function is largely unknown. It has been reported that similar with certain tumor suppressors, it donwregulates JNK/MAPK signaling to exert inhibition on growth and proliferation. ZMYND10 is implicated in the respiratory ciliary dyskinesia....
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