Loss of genetic material from the long arm of chromosome 9 is a common finding in patients with hematological malignancies. These deletions can result from true loss of 9q or complex rearrangements such as dicentric chromosomes, unbalanced translocations, and formation of an isochromosome of the short arm of chromosome 9. Isochromosome i(9)(p10) is an infrequent event that has been described mainly in myeloid malignancies and B-cell lymphomas....

Isochromosome of the short arm of chromosome 5 is an infrequent chromosome anomaly that has been reported in myeloid, and less frequently in in lymphoid malignancies, including leukemia and lymphomas....

Acute promyelocytic leukemia (APL) is characterized by the clonal expansion of myeloid precursors blocked at promyelocytic stage and the presence of t(15;17)(q24;q21) resulting in the fusion of retinoic acid receptor alpha (RARA) gene on 17q21.1 with promyelocytic leukemia (PML) gene at 15q24.1, and less frequently with other gene partners. Fusion between RARA and the interferon regulatory factor 2 binding protein 2 (IRF2BP2) genes is a rare variant translocation in APL....

Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. To date, numerous PDGFRB fusion partners have been identified, with the vast majority being reported only in sporadic cases. Although PDGFRB fusions are rare, their identification is important in order to identify patients in whom targeted therapy with tyrosine kinase inhibitors is likely to be successful....

Chromosome 20 anomalies are well-known in hematological malignancies, being del(20q) and dicentric chromosome 20 the most frequent. In contrast, monosomy 20 that occurs in a variety of hematological neoplasms is less well characterized....