Rare translocation. Because of its rarity, the clinical significance of der(17)t(17;17)(p13;q12-21) is unknown....

Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. To date, numerous PDGFRB fusion partners have been identified, with the vast majority being reported only in sporadic cases. Although PDGFRB fusions are rare, their identification is important in order to identify patients in whom targeted therapy with tyrosine kinase inhibitors is likely to be successful....

Chromosome 20 anomalies are well-known in hematological malignancies, being del(20q) and dicentric chromosome 20 the most frequent. In contrast, monosomy 20 that occurs in a variety of hematological neoplasms is less well characterized....